TY - JOUR
AU - GARDNER, LYTT, I.
AB - ABSTRACT The eleventh known kindred with a vertical pattern of familial male sex precocity is described. Linkage data on blood groups and the phenylthiourea (PTC) taste test were obtained. There is limited evidence for linkage between the Kidd (Jkb) blood groups and the syndrome of familial male precocity. No urinary FSH could be detected in any of the affected children so tested. There was no evidence of ICSH activity in the urine of the propositus, which is against the hypothesis that this syndrome is due to overproduction of ICSH. The urinary C19 steroids of the propositus and his father (also affected) were fractionated on a chromatographic column. The propositus showed dehydroepiandrosterone (DHA) in his urine, whereas normal boys of a similar age did not. The urinary androsterone (ANDRO) in the affected boy was 4 times the concentration in the urine of the control boys. His urinary etiocholanolone (ETIO), 11-OH-ETIO, 11-O-ETIO and 11-OH-ANDRO were about double the excretion of these steroids by the normal boys. Paradoxically, the father excreted less of these C19 steroids, except for 11-O-ETIO, than did the control men. This content is only available as a PDF. Author notes This study was aided by Grants 2A-5277 and A-2504, National Institutes of Health, USPHS. 1 Postdoctoral trainee, National Institute of Arthritis and Metabolic Diseases. 2 Fellow of the National Foundation. Copyright © 1962 by The Endocrine Society
TI - Familial Male Sexual Precocity: Report of the Eleventh Kindred Found, with Observations on Blood Group Linkage and Urinary C19-Steroid Excretion
JF - Journal of Clinical Endocrinology and Metabolism
DO - 10.1210/jcem-22-11-1095
DA - 1962-11-01
UR - https://www.deepdyve.com/lp/oxford-university-press/familial-male-sexual-precocity-report-of-the-eleventh-kindred-found-qN6c20rla4
SP - 1095
VL - 22
IS - 11
DP - DeepDyve
ER -