TY - JOUR
AU - Coleman, Douglas L
AB - L a s k e r b a s i c m e d i c a L resear ch award c o m m e n ta ry Douglas L Coleman As the only child of a self-employed and largely that the db mutation is on chromosome 4 and, self-taught Canadian radio-and-refrigeration like the ob/ob mutant mouse, the db/db mouse repairman, I spent much of my childhood develops marked obesity and hyperphagia, but, investigating how things worked by taking unlike the ob/ob mutant, it develops severe, them apart. As I grew older, I developed a life-shortening diabetes . Figure 1 illustrates keen interest in science, and, while I was an the striking obesity of the db/db mutant undergraduate at McMaster University, my mouse compared with a normal littermate at scientific interests converged on biology, geol- eight weeks of age. The db/db mouse is much ogy and chemistry. During this time, a very larger than the normal mouse (30 grams com- dynamic biochemistry professor encouraged pared with 20 grams), and the extra weight is me to attend graduate school at the University all adipose tissue. Because both ob/ob and db/ of Wisconsin and study biochemistry. Upon db mice become 
TI - A historical perspective on leptin
JF - Nature Medicine
DO - 10.1038/nm1010-1097
DA - 2010-10-01
UR - https://www.deepdyve.com/lp/springer-journals/a-historical-perspective-on-leptin-qCZdcFYPhp
SP - 1097
EP - 1099
VL - 16
IS - 10
DP - DeepDyve
ER -