TY - JOUR
AU - Fried, David M.
AB - 
        It has been reported that patients with amyotrophic lateral sclerosis (ALS) are deficient in exocrine secretion of the pancreas, and that treatment of ALS with large dosages of pancreatic extract and DL-alpha tocopherol (vitamin E) given with a diet high in protein and low in fat and carbohydrate beneficially modifies the course of the disease.1-3 This brief report summarizes our experience with such a treatment program given to patients with ALS who have participated in an ongoing series of drug trials over the past three years and demonstrates the merit of serial quantitative muscle testing (QMT) to evaluate the course of the patients.
        
          Methods
          The diagnosis of ALS was based upon the following clinical observations, which are applicable to these patients but not intended to be general criteria for diagnosing every case of ALS: (1) onset during middle-age or later of a sub-acutely progressive disorder characterized by (2) "anterior
        
      
TI - Therapeutic Trial in Amyotrophic Lateral Sclerosis
JF - JAMA
DO - 10.1001/jama.1969.03160150043011
DA - 1969-07-14
UR - https://www.deepdyve.com/lp/american-medical-association/therapeutic-trial-in-amyotrophic-lateral-sclerosis-qAL1bEkBYF
SP - 257
EP - 258
VL - 209
IS - 2
DP - DeepDyve
ER -