TY - JOUR
AU1 - Pinner, Robert W.
AU2 - Onyango, Francis
AU3 - Perkins, Bradley A.
AU4 - Mirza, Nazir B.
AU5 - Ngacha, Dorothy M.
AU6 - Reeves, Michael
AU7 - DeWitt, Wallis
AU8 - Njeru, Erastus
AU9 - Agata, Naphtali N.
AU1 - Broome, Claire V.
AB - An epidemic of meningococcal disease occurred in Nairobi, Kenya, during 1989, outside the “meningitis belt” of sub-Saharan Africa. About 3800 cases occurred between April and November (250/100,000 population). The case-fatality rate was 9.4% among hospitalized patients. Areas that included Nairobi's largest slums had particularly high attack rates. The epidemic displayed an unusual age distribution, with high attack rates among those 20–29 years old. A vaccination campaign was conducted. By early January, the weekly case count had fallen to 25 from a high of 272 (in September). A case-eontrol study estimated the vaccine efficacy to be 87% (95% confidence interval, 67%–95%). A model estimated that the vaccination campaign reduced the number of cases by at least 20%. Multilocus enzyme electrophoretic typing demonstrated that the strain responsible for this large epidemic is closely related to strains that caused other recent epidemics, documenting further spread of what may be a particularly virulent clonal complex of group A Neisseria meningitidis.
TI - Epidemic Meningococcal Disease in Nairobi, Kenya, 1989
JF - The Journal of Infectious Diseases
DO - 10.1093/infdis/166.2.359
DA - 1992-08-01
UR - https://www.deepdyve.com/lp/oxford-university-press/epidemic-meningococcal-disease-in-nairobi-kenya-1989-pxCR0SvFK9
SP - 359
EP - 364
VL - 166
IS - 2
DP - DeepDyve
ER -