TY - JOUR
AU1 - Waruwu, Syukur Berkat
AU2 - Harahap, Urip
AU3 - Yuandani, Yuandani
AU4 - Purnomo, Hari
AU5 - Satria, Denny
AU6 - 
AB - version 2 Background: Inflammation is a normal protective response caused by tissue damage through physical trauma, chemical damage, or (revision) invasion of pathogenic microorganisms. 1,3-bis(p-hydroxyphenyl)urea 20 Sep 2022 is a modified p-aminophenol compound, which is considered to have strong analgesic activity based on cyclooxygenase-2 inhibition and has version 1 fewer hepatotoxic side effects. In-silico test showed 1,3-bis(p- view view 13 Apr 2022 hydroxyphenyl)urea has COX-1 and TNF- binding activity, so it has the potential to be developed as an anti-inflammatory agent. Anti- 1. Palwinder Singh, Guru Nanak Dev inflammatory activity was tested using mice. Toxicity test was University, Amritsar, India conducted to test the safety of 1,3-bis(p-hydroxyphenyl)urea. Methods: Anti-inflammatory test was carried out by measuring the 2. Neng Fisheri Kurniati , Bandung Institute percentage of inflammation in rat paws using a plethysmometer after administration of 1,3-bis(p-hydroxyphenyl)urea induced by of Technology, Bandung, Indonesia carrageenan 1%, and then histology was performed to observe the Any reports and responses or comments on the number of neutrophils. A toxicity test using OECD guidelines carried out acute toxicity for 24 hours and was observed for 14 days. The article can be found at the end of the article. subchronic toxicity test was carried out 
TI - Anti-inflammatory activity and toxicity evaluation of 1,3-bis(p-hydroxyphenyl)urea
JF - F1000Research
DO - 10.12688/f1000research.77443.2
DA - 2022-09-20
UR - https://www.deepdyve.com/lp/unpaywall/anti-inflammatory-activity-and-toxicity-evaluation-of-1-3-bis-p-ppfKPycZuy
DP - DeepDyve
ER -