TY - JOUR
AU1 - Trabanelli, Sara
AU2 - Ercolano, Giuseppe
AU3 - Wyss, Tania
AU4 - Gomez‐Cadena, Alejandra
AU5 - Falquet, Maryline
AU6 - Cropp, Daniela
AU7 - Imbratta, Claire
AU8 - Leblond, Marine M
AU9 - Salvestrini, Valentina
AU1 - Curti, Antonio
AU1 - Adotevi, Olivier
AU1 - Jandus, Camilla
AU1 - Verdeil, Grégory
AB - Group‐2 innate lymphoid cells (ILC2s), which are involved in type 2 inflammatory diseases such as allergy, can exhibit immunological memory, but the basis of this ILC2 "trained immunity" has remained unclear. Here, we found that stimulation with IL‐33/IL‐25 or exposure to the allergen papain induces the expression of the transcription factor c‐Maf in mouse ILC2s. Chronic papain exposure results in high production of IL‐5 and IL‐13 cytokines and lung eosinophil recruitment, effects that are blocked by c‐Maf deletion in ILCs. Transcriptomic analysis revealed that knockdown of c‐Maf in ILC2s suppresses expression of type 2 cytokine genes, as well as of genes linked to a memory‐like phenotype. Consistently, c‐Maf was found highly expressed in human adult ILC2s but absent in cord blood and required for cytokine production in isolated human ILC2s. Furthermore, c‐Maf‐deficient mouse or human ILC2s failed to exhibit strengthened (“trained”) responses upon repeated challenge. Thus, the expression of c‐Maf is indispensable for optimal type 2 cytokine production and proper memory‐like responses in group‐2 innate lymphoid cells.
TI - c‐Maf enforces cytokine production and promotes memory‐like responses in mouse and human type 2 innate lymphoid cells
JF - The EMBO Journal
DO - 10.15252/embj.2021109300
DA - 2022-06-14
UR - https://www.deepdyve.com/lp/wiley/c-maf-enforces-cytokine-production-and-promotes-memory-like-responses-pkSdGv0LiD
VL - 41
IS - 12
DP - DeepDyve
ER -