TY - JOUR
AU1 - Madero, Juan G. Sierra
AU2 - Toossi, Zahra
AU3 - Hom, David L.
AU4 - Finegan, Candace K.
AU5 - Hoenig, Eric
AU6 - Rich, Elizabeth A.
AB - The level of human immunodeficiency virus type 1 (HIV-1) in lymphocytes and mononuclear phagocytes (MP) from the blood and pulmonary alveoli from 14 HIV-1-infected subjects during early (asymptomatic) and late (AIDS) stages of disease and the relationship between virus burden in MP and cytokine expression were assessed. Among asymptomatic subjects, HIV-1 was undetectable or low in both blood monocytes and alveolar macrophages (AM). Among subjects with AIDS, there was a significant increase of HIV-1 in AM but not monocytes. The level of HIV-1 in blood lymphocytes was higher than in either monocytes or AM. AM (but not monocytes) expressed increased levels of lipopolysaccharide-stimulated cytokine mRNA (tumor necrosis factor-α, interleukin-1β, interleukin-6) during both early and late stages of HIV-1 infection regardless of virus load. AM thus may serve as a reservoir for virus in late stages of disease yet contribute to the immunopathogenesis of lung disease in both early and late stages through increased cytokine expression.
TI - Relationship between Load of Virus in Alveolar Macrophages from Human Immunodeficiency Virus Type 1-Infected Persons, Production of Cytokines, and Clinical Status
JF - The Journal of Infectious Diseases
DO - 10.1093/infdis/169.1.18
DA - 1994-01-01
UR - https://www.deepdyve.com/lp/oxford-university-press/relationship-between-load-of-virus-in-alveolar-macrophages-from-human-pk1b9H8fPB
SP - 18
EP - 27
VL - 169
IS - 1
DP - DeepDyve
ER -