TY - JOUR
AB - To the Editor: Herman and Baylin (Nov. 20 issue)1 provide an excellent review of gene silencing in cancer in association with promoter hypermethylation. However, some readers who are new to the field will be confused by the introductory section of their article — in particular, the authors' explanation of the term “epigenetic,” which suggests that this term describes “a heritable change in the pattern of gene expression.” In fact, in this context, promoter hypermethylation is a somatic event, and although it may be passed on to daughter somatic cells, it is not heritable in the germ line. Although it is . . .
TI - Gene Silencing
JF - The New England Journal of Medicine
DO - 10.1056/NEJM200402263500920
DA - 2004-02-26
UR - https://www.deepdyve.com/lp/the-new-england-journal-of-medicine/gene-silencing-pbAkQv46wn
SP - 947
EP - 948
VL - 350
IS - 9
DP - DeepDyve
ER -