TY - JOUR
AU1 - Simm, A.
AU2 - Nestler, M.
AU3 - Hoppe, V.
AB - Basic Res Cardiol 93: Suppl 3, 40 – 43 (1998) © Steinkopff Verlag 1998 A. Simm Mitogenic effect of PDGF-AA on cardiac M. Nestler fibroblasts V. Hoppe Myocardial infarction and subsequent heart failure is a major PDGF is proposed to be a regulator of vascular cell growth. cause of death. The elucidation of the mechanisms involved in Evidence has been accumulating so far, indicating that PDGF cardiac growth and adaptation processes constitute a major plays a pivotal role in the pathogenesis of arteriosclerosis (4, field of investigation. A principal way of adaptation of the 20) and the evolution of chronic arterial obstructive disease heart after myocardial infarction and consecutive hemody- (CAOD). Patients with severe CAOD have a more than three- namic load is compensatory growth (hypertrophy). This fold increase in PDGF plasma levels than control patients (6). increase in heart/body weight ratio is due to an increase in PDGF is a major mitogen in serum (8, 20) whose two myocyte mass and a simultaneous development of a myocar- homologous chains, termed A and B, can combine to three dial fibrosis. This remodeling of the cardiac interstitium is different biological active dimeric isoforms: AA, AB, and BB. accompanied by a 
TI - Mitogenic effect of PDGF-AA on cardiac fibroblasts
JF - Basic Research in Cardiology
DO - 10.1007/s003950050209
DA - 1998-12-01
UR - https://www.deepdyve.com/lp/springer-journals/mitogenic-effect-of-pdgf-aa-on-cardiac-fibroblasts-pZ5t61khHf
SP - s040
EP - s043
VL - 93
IS - 3
DP - DeepDyve
ER -