TY - JOUR AU1 - Balayan, M.S. AU2 - Andjaparidze, A.G. AU3 - Savinskaya, S.S. AU4 - Ketiladze, E.S AU5 - Braginsky, D.M. AU6 - Savinov, A.P. AU7 - Poleschuk, V.F. AB - Typical acute hepatitis was reproduced in a human volunteer immune to hepatitis A virus (HAV) after oral administration of pooled stool extracts from presumed cases of epidemic non-A, non-B hepatitis. Markers of hepatitis B infection, anti-HAV IgM, and increase in total anti-HAV level were not detectable in the volunteer’s sera during the course of infection. Spherical 27- to 30-nm virus-like particles were visualized by immune electron microscopy (IEM) in stool samples collected during preclinical and early postclinical phases. These particles banded in CsCl at a buoyant density of 1.35 g/cm3. They reacted in the IEM test with sera from individuals who had experienced two non-B hepatitis episodes but did not react with sera from routine anti-HAV IgM-positive hepatitis patients. Intravenous inoculation of cynomolgus monkeys with the virus-containing stool extract resulted in histopathologically and enzymatically confirmed hepatitis, excretion of virus-like particles, and antibody response to them. TI - Evidence for a Virus in Non-A, Non-B Hepatitis Transmitted via the Fecal-Oral Route JF - Intervirology DO - 10.1159/000149370 DA - 2008-01-01 UR - https://www.deepdyve.com/lp/karger/evidence-for-a-virus-in-non-a-non-b-hepatitis-transmitted-via-the-pTUMOOk5xi SP - 23 EP - 31 VL - 20 IS - 1 DP - DeepDyve ER -