TY - JOUR
AU - Linder, Mark, W
AB - A balanced mix of academic and commercial scientists have compiled the essential information necessary for a critical comparison of automated immunoassay systems. This text focuses on systems that are fully automated, dedicated analyzers for immunodiagnostics, combining continuous access, primary tube sampling, bar-code reading, sophisticated information processing, and a diverse menu of available analytes to provide for workstation consolidation. The book begins with an excellent overview of the role of random-access immunoassay analyzers in addressing the challenges to today’s hospital laboratories and guiding hospital laboratory design of the future. The authors also discuss the future needs of automated immunoassay analyzers, including miniaturization, more specific antibodies, high signal labels, system integration, and test mix that transcends current lines of specialty, e.g., microbiology, hematology, chemistry, and toxicology. The remaining chapters describe and critique individual automated immunoassay systems, with chapters on AxSym, Opus Magnum, Vidas, ACS:180 plus, Immulite, aca plus, Immuno 1, Cobas Core, Access, AIA-1200, and AutoDELFIA. Two chapters introduce exciting new technology with promise for improved automated immunodiagnostic systems of the future, and the final chapter describes a universal ELISA format applicable for assay development and research. A welcome addition to the book would be a section on immunoassay theory and design, including essential basics needed for comprehending the tremendous advances that have been made in immunoassay automation as well as the potential limitations of the systems described. Each of the chapters covering automated immunodiagnostic systems includes an excellent system description, complete with informative diagrams, a general description of the method principles employed by the assay, the menu of available tests, and various levels of system performance evaluation, which ranged from minimal data readily available in reagent package inserts to extensive evaluations by independent laboratories. Among the most informative chapters were those that provided independent analytical data either from the author’s laboratory or from the peer-reviewed literature. These chapters included linearity based on true patient samples, recovery, correlation to established assays from competitive manufacturers, detailed interference studies, and an unbiased critical review supported by references to the current literature. Some of the chapters have promotional content, but not at the expense of the information necessary to make a cursory comparison with the other systems included in the text. This book is a tremendous resource and recommended reading for all laboratorians or manufacturers interested either in purchasing an automated immunoassay system or in understanding the current and future roles of these analyzers in meeting the challenges to today’s practice of clinical laboratory medicine. © 1997 The American Association for Clinical Chemistry This article is published and distributed under the terms of the Oxford University Press, Standard Journals Publication Model (https://academic.oup.com/journals/pages/open_access/funder_policies/chorus/standard_publication_model)
TI - Immunoassay Automation: an Updated Guide to Systems. D.W. Chan, ed. San Diego: Academic Press, Inc., 1996, 312 pp. $59.95. ISBN 0-12-167640-4.
JF - Clinical Chemistry
DO - 10.1093/clinchem/43.2.418
DA - 1997-02-01
UR - https://www.deepdyve.com/lp/oxford-university-press/immunoassay-automation-an-updated-guide-to-systems-d-w-chan-ed-san-pDMBO0CTu6
SP - 418
EP - 418
VL - 43
IS - 2
DP - DeepDyve
ER -