TY - JOUR
AU - Finberg, Robert W.
AB - Prokaryotic and eukaryotic cells respond to a variety of stress conditions by increasing the synthesis of a family of proteins collectively known as heat-shock proteins (HSP). One of these, a 65-kDa HSP that is highly conserved in many bacteria, is a major target of the immune response to mycobacteria. A γδ T cell clone from a healthy donor that recognizes not only the 65-kDa mycobacterial HSP but also the recombinant human homologue of this HSP protein was raised. Like ocfJ T cell clones, which recognize mycobacterial HSP, the clone requires antigen-presenting cells for antigen-induced proliferation and can also bedirectly activated via receptor cross-linking through CD3 or the δ chain of the γδ T cell receptor. These data suggest that the induction of a γδ T cell response by bacterial antigens could lead to the expansion of cells that respond to autologous proteins and, therefore, may result in the development of autoimmunity.
TI - A Mycobacterial Heat-Shock Protein-Responsive γδ T Cell Clone Also Responds to the Homologous Human Heat-Shock Protein: A Possible Link between Infection and Autoimmunity
JF - The Journal of Infectious Diseases
DO - 10.1093/infdis/163.1.156
DA - 1991-01-01
UR - https://www.deepdyve.com/lp/oxford-university-press/a-mycobacterial-heat-shock-protein-responsive-t-cell-clone-also-p28aa0xupO
SP - 156
EP - 160
VL - 163
IS - 1
DP - DeepDyve
ER -