TY - JOUR
AU1 - Tsuruoka, S.
AB - Introduction This review deals with the functional significance of multidrug resistance protein (MDR) in the renal proximal The kidney is one of the major organs in which hydrophilic tubule, and the possible application of MDR to an artificial drugs and/or poisons are removed from body. There are “hybrid kidney” for the treatment of digoxin intoxication. three mechanisms for the excretion of such substances Rhodamine 123 was used as a fluorescent substrate of MDR by the kidney; glomerular filtration, tubular secretion, and to measure the efflux of the drug across the luminal mem- passive diffusion. The total amount of drug secretion into brane in isolated perfused mouse proximal tubules. The urine is determined by the sum total of the drug secreted efflux was completely blocked by the addition of verapamil by these three mechanisms. In tubular secretion, organic to the lumen. In the proximal tubule from mdr1a/1b double- anion transporters (OATs) and organic cation transporters knockout mice, the secretion of rhodamine 123 was com- 2,3 (OCTs) are well recognized as the major transporters. pletely blunted. Another substrate of MDR, digoxin, after Other transporters, which can contribute to the secretion of repeated administration, accumulated in the kidney to a some xenobiotics, 
TI - Secretion of xenobiotics via multidrug resistance protein (MDR) in kidney: application to development of artificial "hybrid kidney"
JF - Clinical and Experimental Nephrology
DO - 10.1007/s101570170001
DA - 2001-09-01
UR - https://www.deepdyve.com/lp/springer-journals/secretion-of-xenobiotics-via-multidrug-resistance-protein-mdr-in-p0D1DAa7Ab
SP - 137
EP - 143
VL - 5
IS - 3
DP - DeepDyve
ER -