TY - JOUR
AU - Kwan, Chiu-Yin
AB - Abstract The pharmacological profiles of the active ingredients extracted and purified from two well-known Chinese traditional medicinal plants were reviewed. These herbal drugs include tetramethylpyrazine (TMP) and tetrandrine (TET); both have been clinically used in China for the treatment of cardiovascular diseases due to their vasodilatory actions. Studies from this laboratory have confirmed previously reported characteristics of TMP as a Ca2+ antagonist in vascular tissues. However, it also elicited inhibitory effects in response to a wide variety of receptor stimulations as indicated by functional studies and radioligand binding studies using isolated subcellular membranes. TET also inhibited the vascular contraction in response to depolarization by KCI and phenylephrine. It has been found to interact directly with the L-type Ca2+ channel and α-adrenoceptor subtypes. Recently, its action on T-type Ca2+ channels has also been demonstrated. These findings collectively suggest that studies of the vasodilatory and antihypertensive effects of these plant-derived drugs on the regulation of cytosolic Ca2+ in vascular smooth muscle are consistent with the current hypothesis of Ca2+ dysfunction as an important etiological factor for the pathogenesis of hypertension. Vascular smooth muscle, Calcium, Natural products, Tetramethylpyrazine, Tetrandrine, Traditional medicine, Hypertension, Antihypertensive drugs References 1 Kwan CY . Signal transduction in smooth muscle as studied by subcellular membrane approach . Can J Physiol Pharmacol 1992 ; 70 : 501 – 508 . Google Scholar Crossref Search ADS PubMed WorldCat 2 Kwan CY . The use of fluorescent Ca2+ indicators in the study of Ca2+ handling by living cells: a brief review . Basic Med Clin 1990 ; 10 : 54 – 59 . Google Scholar OpenURL Placeholder Text WorldCat 3 Kwan CY . Membrane biochemistry of vascular smooth muscle of resistance blood vessels and changes in hypertension. 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Google Scholar Crossref Search ADS PubMed WorldCat This content is only available as a PDF. © 1994 AlphaMed Press This article is published and distributed under the terms of the Oxford University Press, Standard Journals Publication Model (https://academic.oup.com/journals/pages/open_access/funder_policies/chorus/standard_publication_model)
TI - Plant-derived drugs acting on cellular ca2+ mobilization in vascular smooth muscle: Tetramethylpyrazine and tetrandrine
JO - Stem Cells
DO - 10.1002/stem.5530120111
DA - 1994-01-01
UR - https://www.deepdyve.com/lp/oxford-university-press/plant-derived-drugs-acting-on-cellular-ca2-mobilization-in-vascular-ovhf0cBYIN
SP - 64
EP - 67
VL - 12
IS - 1
DP - DeepDyve
ER -