TY - JOUR
AU1 - King, Thomas, C.
AU2 - Schlessinger,, David
AU3 - Krogstad, Donald, J.
AB - Abstract The traditional approach to the study of the interaction between antimicrobial agents relies on the assumption that inhibition of growth by antimicrobial agents follows a linear dose-response curve. Because this assumption is invalid, we propose that antimicrobial combinations should be assessed by empiric dose-response curves that would distinguish synergistic, additive, and antagonistic effects on the rate of cell growth. This approach predicts synergy for the model combination of trimethoprim and sulfamethoxazole and should also be applicable to other combinations of antimicrobial agents and to combinations of antitumor agents. This content is only available as a PDF. © 1981 by The University of Chicago
TI - The Assessment of Antimicrobial Combinations
JF - Clinical Infectious Diseases
DO - 10.1093/clinids/3.3.627
DA - 1981-05-01
UR - https://www.deepdyve.com/lp/oxford-university-press/the-assessment-of-antimicrobial-combinations-ovdnV9NH8q
SP - 627
EP - 633
VL - 3
IS - 3
DP - DeepDyve
ER -