TY - JOUR
AU - Lee, Sang-Woo
AB - Objective:The current review aimed to investigate the performance of the diagnostic accuracy of 18F- fludeoxyglucose positron emission tomography/CT (PET/CT) in detecting peritoneal carcinomatosis (PC) through a systematic review and meta-analysis. Methods:The MEDLINE via PubMed and EMBASE from the earliest available date of indexing to 31 March 2017, were searched for studies evaluating the diagnostic performance of 18F-FDG PET/CT in detecting PC. We evaluated the pooled sensitivities and specificities across included studies, calculated positive and negative likelihood ratios (LR+ and LR−), and plotted summary receiver operating characteristic curves. Deek’s funnel plot asymmetry tests were used to assess the possible underlying publication bias. Results:The current meta-analysis demonstrated no significant publication bias (p = 0.21). Across 14 studies (671 patients), the overall sensitivity of 18F-FDG PET/CT was 0.87 [95% CI (0.77−0.93)] with heterogeneity (χ 2 = 94.2, p = 0.00) and a pooled specificity of 0.92 [95% CI; (0.89−0.94)] with heterogeneity (χ 2 = 20.6, p = 0.08). LR syntheses gave an overall LR+ of 10.4 [95% CI (7.5−14.5)] and LR− of 0.14 [95% CI (0.08−0.26)]. The pooled diagnostic odds ratio was 73 [95% CI (34−159)]. In univariate meta-regression analysis, publication year and cohort homogeneity were the potent sources of heterogeneity. However, in multivariate meta-regression, no definite variable was the source of the study heterogeneity. Conclusion:18F-FDG PET/CT demonstrated good sensitivity and specificity for the detection of PC. Further large multicentre studies would be necessary to substantiate the diagnostic accuracy of 18F-FDG PET/CT for the diagnosis of PC in various cancers. Advances in knowledge:18F-FDG PET/CT showed good diagnostic performance in the evaluation of PC and could provide additional information for that purpose in various cancers.
TI - Diagnostic accuracy of 18F-FDG PET/CT for detection of peritoneal carcinomatosis; a systematic review and meta-analysis
JF - British Journal of Radiology
DO - 10.1259/bjr.20170519
DA - 2017-11-21
UR - https://www.deepdyve.com/lp/oxford-university-press/diagnostic-accuracy-of-18f-fdg-pet-ct-for-detection-of-peritoneal-omi4rxmoFp
VL - 91
IS - 1081
DP - DeepDyve
ER -