TY - JOUR
AB - S108 Poster presentations Figure 1. (A) Second-harmonic images of mouse colon on the indicated time points over the course of DSS-induced colitis. (B) Comparisons of differentially abundant ECM proteins between the 5 different states. structural and compositional similarity, which is distinct from that Centre (DKFZ), Department of Molecular Immunology, Heidelberg, of the healthy wild-type mouse. Germany, University Hospitals Leuven, KU Leuven, Department of Conclusions: The colonic ECM we observed in early stages of Gastroenterology, Leuven, Belgium inflammation, before onset of symptoms, holds the potential to be Background: MMP-9 is elevated in blood and intestinal tissue of used as predictor of flares in IBD patients. The generation of such IBD patients and is suggested by knockout (KO) mouse and inhibi- ECM, shared between acute and chronic inflammation, indicates the tor studies as a key causal factor. MMP-9 antagonists are presently generation of a pro-inflammatory matrix, potentially providing the evaluated in clinical trials for IBD. Our aim was to reinvestigate the appropriate microenvironmental signals for development of intesti- role of MMP-9 in acute and chronic intestinal inflammation. nal inflammation. Methods: MMP-9 KO mice were backcrossed for 13 generations into C57BL/6J mice and bred under identical environmental condi- tions for >15 years in our 
TI - P038. Revised roles of matrix metalloproteinase/MMP-9 in inflammatory bowel diseases: from target to biomarker
JF - Journal of Crohn's and Colitis
DO - 10.1093/ecco-jcc/jjw019.157
DA - 2016-03-01
UR - https://www.deepdyve.com/lp/oxford-university-press/p038-revised-roles-of-matrix-metalloproteinase-mmp-9-in-inflammatory-olAxWZas9O
SP - S108
EP - S109
VL - 10
IS - suppl_1
DP - DeepDyve
ER -