TY - JOUR
AU - Hayani, Karen
AB - Abstract With concern about vitamin A toxic side effects, Dr Donnelly wonders if the children with respiratory syncytial virus infection in our study1 would have benefited more if we had given them β-carotene, a vitamin A precursor, rather than vitamin A solution. We found that a onetime oral administration of 100 000IU of vitamin A for 21 inpatient children infected with respiratory syncytial virus did not provide any measurable clinical benefit or cause vitamin A toxic effects. The dose of vitamin A in our study was based on the World Health Organization–United Nations International Children's Emergency Fund recommendations for the use of vitamin A for measles.2 Evidence from African studies3-5 have shown that vitamin A, not β-carotene, benefits patients with measles. The mean serum retinol levels in children with acute measles infection in those studies were approximately half of that in the US children with respiratory syncytial virus References 1. Quinlan KP, Hayani KC. Vitamin A and respiratory syncytial virus infection: serum levels and supplementation trial . Arch Pediatr Adolesc Med . 1996;150:25-30.Crossref 2. Joint WHO/UNICEF Statement. Vitamin A for measles . Wkly Epidemiol Rec . 1987;62:133-140. 3. Barclay AJG, Foster A, Sommer A. Vitamin A supplements and mortality related to measles: a randomized clinical trial . BMJ . 1987;294:294-296.Crossref 4. Coutsoudis A, Broughton M, Coovadia HM. Vitamin A supplementation reduces measles morbidity in young African children: a randomized, placebocontrolled, double-blind trial . Am J Clin Nutr . 1991;54:890-895. 5. Hussey GD, Klein M. A randomized, controlled trial of vitamin A in children with severe measles . N Engl J Med . 1990;323:160-164.Crossref
TI - Vitamin A and Respiratory Syncytial Virus Infection-Reply
JF - Archives of Pediatrics & Adolescent Medicine
DO - 10.1001/archpedi.1996.02170330108022
DA - 1996-08-01
UR - https://www.deepdyve.com/lp/american-medical-association/vitamin-a-and-respiratory-syncytial-virus-infection-reply-ocdisfdQmf
SP - 882
EP - 882
VL - 150
IS - 8
DP - DeepDyve
ER -