TY - JOUR AU1 - Guéguinou, Nathan AU2 - Huin-Schohn, Cécile AU3 - Bascove, Matthieu AU4 - Bueb, Jean-Luc AU5 - Tschirhart, Eric AU6 - Legrand-Frossi, Christine AU7 - Frippiat, Jean-Pol AB - Review describes hazards present as humans explore space and focuses on the effects of spaceflight on immunity.This year, we celebrate the 40th birthday of the first landing of humans on the moon. By 2020, astronauts should return to the lunar surface and establish an outpost there that will provide a technical basis for future manned missions to Mars. This paper summarizes major constraints associated with a trip to Mars, presents immunological hazards associated with this type of mission, and shows that our current understanding of the immunosuppressive effects of spaceflight is limited. Weakening of the immune system associated with spaceflight is therefore an area that should be considered more thoroughly before we undertake prolonged space voyages. TI - Could spaceflight-associated immune system weakening preclude the expansion of human presence beyond Earth’s orbit? JF - Journal of Leukocyte Biology DO - 10.1189/jlb.0309167 DA - 2009-08-18 UR - https://www.deepdyve.com/lp/oxford-university-press/could-spaceflight-associated-immune-system-weakening-preclude-the-obJmeBeA7W SP - 1027 EP - 1038 VL - 86 IS - 5 DP - DeepDyve ER -