TY - JOUR
AU - Science Journal, Baghdad
AB - In this work, a series of new Nucleoside analogues (D-galactopyranose linked to oxepanebenzimidazole moiety) was synthesized via multisteps synthesis. The first step involved preparation of two benzimidazoles 2- styrylbenzimidazole and 2-(phenyl ethynyl) benzimidazole via reaction of phenylenediamine with cinnamic acid or β-phenyl propiolic acid. Electrophilic addition of the prepared benzimidazoles by three anhydrides in the second step afforded (4-6) and (14-16) which in turn were treated with 1,2,3,4-di-O- isopropylidene galactopyranose in the third step to afford a series of the desirable protected nucleoside analogues (7-9) ,(17-19)which after hydrolysis in methanolic sodium methoxidein the fourth step afforded the free nucleoside analogues (10-12) and (20-22) .The synthesized compounds were identified by FT-IR and some of them 1 13 by H-NMR and C-NMR. The synthesized oxepane nucleoside analogues were screened for their antibacterial activity against three types of bacteria including Staphylococcusaureus ,Bacillus(gram positive) andE.coli (gram negative) bacteria repectively. Key words: Nucleoside, oxepane nucleoside, isopropyledenegalactopyranose. Introduction: Oxepane diones that are heterocyclic and inhibition of several enzyme compounds with seven-membered activities [2]. Also they applied as oxycyclic are found in a number of achemotherapeutic used to treat natural products such as zoapatanol advanced brain tumors[3],[4]. ,regiolenyne and breveral [1]. Nowaday On the other hand, 
TI - Synthesis of Some New Nucleoside Analogues Containing Seven Membered Ring and Studying Their Biological Activity
JF - Baghdad Science Journal
DO - 10.21123/bsj.13.3.531-546
DA - 2016-09-04
UR - https://www.deepdyve.com/lp/unpaywall/synthesis-of-some-new-nucleoside-analogues-containing-seven-membered-oCEOS3D73Q
DP - DeepDyve
ER -