TY - JOUR
AU - Martin, Javier
AB - Described in detail is the molecular epidemiology of wild-type 1 poliovirus circulation in Ghana between 19952008, following the implementation of a surveillance system for cases of acute flaccid paralysis and poliovirus infection. Molecular phylogenetic analysis combined with a detailed evaluation of epidemiological indicators revealed that the geographical and temporal circulation of wild-type poliovirus in Ghana was determined by the quality of the implementation of global eradication strategies. The transmission of indigenous wild-type 1 poliovirus was eliminated in 1999. However, a drastic reduction in national immunization campaigns resulted in the importation in 2003 and 2008 of wild-type 1 poliovirus from neighboring countries. Both outbreaks were promptly interrupted following resumption of immunization activities. The results detailed here provide scientific evidence that supports the feasibility of polio eradication in Central West Africa, one of the remaining endemic areas for the disease, provided that comprehensive immunization campaigns and sensitive surveillance systems are in place.
TI - Interruption of Poliovirus Transmission in Ghana: Molecular Epidemiology of Wild-Type 1 Poliovirus Isolated from 1995 to 2008
JO - The Journal of Infectious Diseases
DO - 10.1093/infdis/jis474
DA - 2012-10-01
UR - https://www.deepdyve.com/lp/oxford-university-press/interruption-of-poliovirus-transmission-in-ghana-molecular-nwXMHR4qpO
SP - 1111
EP - 1120
VL - 206
IS - 7
DP - DeepDyve
ER -