TY - JOUR AU - Behera, Tusharkantee AB - Laboratory Medicine, 2025, 56, 81–84 https://doi.org/10.1093/labmed/lmae051 Advance access publication 25 July 2024 Case Study Navigating the conundrum of co-existing autoantibodies and alloantibodies in a case of Evans syndrome 1 2 1 Pallabi Dash, MBBS, MD , Nilasish Pani, MBBS , Jayant Kumar Panda, MBBS, MD , 2 2 Smita Mahapatra, MBBS, MD , Binay Bhusan Sahoo, MBBS, MD , Tusharkantee Behera, MBBS, MD Department of Medicine, SCB Medical College and Hospital, Cuttack, Odisha, India; Department of Transfusion Medicine, SCB Medical College and Hospital, Cuttack, Odisha, India Corresponding author: Pallabi Dash; 02pallabi07@gmail.com Key words: autoimmune hemolytic anemia; Evans syndrome; alloantibodies; purpura; thrombocytopenic; idiopathic; blood transfusion; autoantibodies; immunoglobulins; intravenous; steroids; transfusion reaction Abbreviations: DAT, direct antiglobulin test; Ig, immunoglobulin; PRBCs, packed red blood cells; SLE, systemic lupus erythematosus; NHL, non-Hodgkin lymphoma; CLL, chronic lymphocytic leukemia C a se R e p or t a 3+ polyspecific reaction. Monospecific testing revealed posi - tivity for immunoglobulin (Ig)G binding to red blood cells Patient History (3+), whereas C3d was negative. Auto control demonstrated An 18-year-old nulliparous female presented with heavy men- temperature-dependent agglutination, with a stronger reac- strual bleeding and fatigue. Her complaints started 20 days prior, tion at 37°C (4+) compared with TI - Navigating the conundrum of co-existing autoantibodies and alloantibodies in a case of Evans syndrome JF - Laboratory Medicine DO - 10.1093/labmed/lmae051 DA - 2024-07-25 UR - https://www.deepdyve.com/lp/oxford-university-press/navigating-the-conundrum-of-co-existing-autoantibodies-and-nq2zQvRFV7 SP - 81 EP - 84 VL - 56 IS - 1 DP - DeepDyve ER -