TY - JOUR
AU1 - Sasaki, Tasuku
AU2 - Hirabayashi, Jun
AU3 - Manya, Hiroshi
AU4 - Kasai, Ken-ichi
AU5 - Endo, Tamao
AB - Brain-derived neurotrophic factor (BDNF) is a neuroprotective polypeptide that is thought to be responsible for neuron proliferation, differentiation, and survival. An agent that enhances production of BDNF is expected to be useful for the treatment of neurodegenerative diseases. Here we report that galectin-1, a member of the family of β-galactoside binding proteins, induces astrocyte differentiation and strongly inhibits astrocyte proliferation, and then the differentiated astrocytes greatly enhance their production of BDNF. Induction of astrocyte differentiation and BDNF production by an endogenous mammalian lectin may be a new mechanism for preventing neuronal loss after injury.
TI - Galectin-1 induces astrocyte differentiation, which leads to production of brain-derived neurotrophic factor
JF - Glycobiology
DO - 10.1093/glycob/cwh043
DA - 2004-04-01
UR - https://www.deepdyve.com/lp/oxford-university-press/galectin-1-induces-astrocyte-differentiation-which-leads-to-production-noW7S0Ile1
SP - 357
EP - 363
VL - 14
IS - 4
DP - DeepDyve
ER -