TY - JOUR
AU - Pajunen, A. E.
AB - Mammalian Genome 7,776-779 (1996). e//o///e 9 Springer-Verlag New York Inc. 1996 Rat S-adenosylmethionine decarboxylase gene family: intronic genes are alleles R. Heljasvaara, P. Laajala, T. Soininen, A.E. Pajunen Biocenter and Department of Biochemistry, University of Oulu, FIN-90570 Oulu, Finland Received: 14 March 1996 / Accepted: 5 June 1996 S-Adenosylmethionine decarboxylase (AdoMetDC; EC 4.1.1.50) giving an intron sequence homology of 98% (introns 2 through 7) is one of the key enzymes in the biosynthesis of polyamines that between these two genomic clones. However, the most dramatic appear to be essential for mammalian cell proliferation (Tabor and difference was located in the 5' flanking region where the se- Tabor 1984; Pegg 1986). Decarboxylated AdoMet, the product of quences upstream from nucleotide -63 are totally different. the reaction catalyzed by AdoMetDC, serves as an aminopropyl Because Southern blot analysis revealed still unidentified donor in spermidine and spermine synthesis. Because the content Amd-related fragments, the present work was undertaken to isolate of decarboxylated AdoMet is normally very low in mammalian all the members of rat Amd gene family, the ultimate goal being cells, the flow of putrescine to the higher polyamines is dependent identification of possible rat counterpart for the mouse intronless on 
TI - Rat S-adenosylmethionine decarboxylase gene family: Intronic genes are alleles
JF - Mammalian Genome
DO - 10.1007/s003359900232
DA - 1996-10-01
UR - https://www.deepdyve.com/lp/springer-journals/rat-s-adenosylmethionine-decarboxylase-gene-family-intronic-genes-are-nfFaePDM0N
SP - 776
EP - 779
VL - 7
IS - 10
DP - DeepDyve
ER -