TY - JOUR
AU1 - Göthe, Carl-Johan
AB - The effect of cortisol on the weight of the body, lungs and hilar lymph nodes, and its effect on the lymphatic lung clearance was studied in rats killed two and four months respectively after intratracheal (i.t.) injection with 20 mg of fine-particulate quartz. Cortisol was administered via the drinking water, in a dose of about 0.4 mg per animal per day, during two months before the animals were killed.Cortisol causes the rats to become cachectic and reduces the weight of the hilar lymph nodes, but does not affect the lung weight. It also retards the translocation rate of quartz particles from the lungs to the hilar lymph nodes when cortisol treatment is started immediately or two months after the i.t. quartz-dust injection. This tends to increase the silica content of the lungs and to decrease it in the hilar lymph nodes. The effect on the hilar lymph-node weight is, however, more pronounced than can be explained by the cortisol-induced reduction of the silica content of these nodes.There are no definite indications of specific »anti-quartz« or »anti-silicotic« effects of cortisol on the rat lung under the experimental conditions used.
TI - Effect of Cortisol on Lymphatic Lung Clearance and on Experimental Silicosis
JF - European Journal of Endocrinology
DO - 10.1530/acta.0.0630313
DA - 1970-02-01
UR - https://www.deepdyve.com/lp/oxford-university-press/effect-of-cortisol-on-lymphatic-lung-clearance-and-on-experimental-nOlS6How4a
SP - 313
EP - 324
VL - 63
IS - 2
DP - DeepDyve
ER -