TY - JOUR
AU1 - POORALI, LEYLA
AU2 - KARAMI, BAHADOR
AU3 - ESKANDARI, KHALIL
AU4 - AZIZI, MAHBOOBEH
AB - Abstract In this work, new, efficient and environmentally adapted synthesis of polysubstituted imidazoles in one-pot is repoted. The multicomponent reaction of various aldehydes, benzil, aliphatic and aromatic primary amines and ammonium acetate under solvent-free condition is explained. The highly efficient role of antimony trichloride and stannous chloride dihydrate as catalyst in this synthesis was shown and their effects on the reaction process were studied. By this advantage, several polysubstituted imidazoles as pharmaceutical important molecules can be prepared in high yield and high purity. This method is a very easy and rapid for the synthesis of imidazole derivatives. We report here a simple, rapid and one-pot procedure for the synthesis of tri and tetra-substituted imidazoles by the use of antimony trichloride and stannous chloride dihydrate with high yields and short reaction times under solvent-free conditions.
TI - New and rapid access to synthesis of novel polysubstituted imidazoles using antimony trichloride and stannous chloride dihydrate as effective and reusable catalysts
JF - "Journal of Chemical Sciences"
DO - 10.1007/s12039-013-0395-9
DA - 2013-05-01
UR - https://www.deepdyve.com/lp/springer-journals/new-and-rapid-access-to-synthesis-of-novel-polysubstituted-imidazoles-nDvcnHtPPZ
SP - 591
EP - 599
VL - 125
IS - 3
DP - DeepDyve
ER -