TY - JOUR
AU - ESTENSEN, RICHARD, D.
AB - Phorbol myristate acetate (PMA), a tumor- promoter capable of influencing biologic functions of many cell systems, has been demonstrated to augment glucose-initiated insulin release from isolated rat islets of Langerhans. PMA caused a 2-fold increase in insulin release. This effect of PMA did not alter the sigmoidal relationship of insulin released to glucose concentration. The effect of PMA on insulin secretion from the islet β-cells persists and a challenge with glucose alone, subsequent to a pulse of PMA, elicits an augmented insulin release response. (Endocrinology102: 706, 1978) This content is only available as a PDF. Author notes * Supported by USPHS Grants AM 17697 and CA 16223. † Recipient of an NIH Postdoctoral Fellowship no. 1F32 AM5527-01. ‡ To whom requests for reprints should be addressed. Copyright © 1978 by The Endocrine Society
TI - Phorbol Myristate Acetate: Effect of a Tumor Promoter on Insulin Release from Isolated Rat Islets of Langerhans
JF - Endocrinology
DO - 10.1210/endo-102-3-706
DA - 1978-03-01
UR - https://www.deepdyve.com/lp/oxford-university-press/phorbol-myristate-acetate-effect-of-a-tumor-promoter-on-insulin-n0xKPoYML2
SP - 706
EP - 711
VL - 102
IS - 3
DP - DeepDyve
ER -