TY - JOUR
AU1 - Liang, Jia-Jie
AU2 - Peng, Hu
AU3 - Wang, Jiao-Jiao
AU4 - Liu, Xiao-Hui
AU5 - Ma, Lan
AU6 - Ni, Yi-Ran
AU7 - Yang, Huai-Jie
AU8 - Zhang, Yan-Qiong
AU9 - Ai, Wen-Bing
AU1 - Wu, Jiang-Feng
AB - E proteins are transcriptional regulators that regulate many developmental processes in animals and lymphocytosis and leukemia in Homo sapiens. In particular, E2A, a member of the E protein family, plays a major role in the transcriptional regulatory network that promotes the differentiation and development of B and T lymphocytes. E2A-mediated transcriptional regulation usually requires the formation of E2A dimers, which then bind to coregulators. In this review, we summarize the mechanisms by which E2A participates in transcriptional regulation from a structural perspective. More specifically, the C-terminal helix-loop-helix (HLH) region of the basic HLH (bHLH) domain first dimerizes, and then the activation domains of E2A bind to different coactivators or corepressors in different cell contexts, resulting in histone acetylation or deacetylation, respectively. Then, the N-terminal basic region (b) of the bHLH domain binds to or dissociates from a specific DNA motif (E-box sequence). Last, trans-activation or trans-repression occurs. We also summarize the properties of these E2A domains and their interactions with the domains of other proteins. The feasibility of developing drugs based on these domains is discussed.
TI - Relationship between the structure and function of the transcriptional regulator E2A
JF - Journal of Biological Research-Thessaloniki
DO - 10.1186/s40709-021-00146-5
DA - 2021-07-16
UR - https://www.deepdyve.com/lp/springer-journals/relationship-between-the-structure-and-function-of-the-transcriptional-mnDly6Mapi
VL - 28
IS - 1
DP - DeepDyve
ER -