TY - JOUR
AU - Ebisu, S.
AB - Previously, we have reported that sealants incorporating bisphenol A dimethacrylateshowed estrogenicity by a reporter gene assay. This study tested the hypothesis thatcommercial composites, which contain various monomers and additives, exhibitestrogenic activity in vitro. The estrogenic activitiesof eluates obtained from 24 composites and 18 chemicals identified from thecomposites tested were examined with the use of the reporter gene assay. Among the 24composites, 6 products were estrogenic, and among the 18 constituents, 1photostabilizer, 2-hydroxy-4-methoxy-benzophenone (HMBP), 1 photoinitiator,2,2-dimethoxy-2-phenyl-acetophenone (DMPA), and 1 inhibitor, 2,6-di-tert-butyl-p-cresol (BHT) hadsignificant estrogenic activity. The concentration of HMBP in 4 estrogenic eluateswas greater than the minimum concentration required for estrogenicity, and DMPA wasfound at a higher level than the minimum estrogenic concentration in the remaining 2estrogenic specimens. These results suggest that the observed estrogenic activity of6 composites is associated with the elution of either HMBP or DMPA.
TI - In vitro Estrogenicity of Resin               Composites
JO - Journal of Dental Research: Featuring Critical Reviews in Oral Biology and Medicine
DO - 10.1177/154405910408300307
DA - 2004-03-01
UR - https://www.deepdyve.com/lp/sage/in-vitro-estrogenicity-of-resin-composites-mmXClw0D9m
SP - 222
EP - 226
VL - 83
IS - 3
DP - DeepDyve
ER -