TY - JOUR
AU - Soussi, Thierry
AB - and two trained pathologists (B. As defined by Rapin et al. (3), eight Bouchind’homme and A. V. Salomon), tumors were atypical medullary breast who were blinded to the status of the carcinomas and 15 tumors were typical BRIEF medullary breast carcinomas. It is inter- specimens, independently reviewed esting that all typical medullary carcino- each specimen during the study. As COMMUNICATION mas harbored a p53 alteration (Table 1) defined by Rapin et al. (3), typical (95% confidence interval [CI] 4 78%– medullary carcinomas display at least 100%). In the eight atypical medullary 75% syncytial architecture, a well- carcinomas examined, only two muta- defined border, diffuse lymphoplasmo- p53 Mutation as a Genetic tions were detected, giving a frequency cytic infiltrate, moderate or marked ani- Trait of Typical Medullary of 25% (95% CI 4 3%–65%), a fre- sonucleosis, and absence of tubular Breast Carcinoma quency similar to that in invasive breast differentiation and/or an intraductal carcinomas. component (2,3) (15 of our 23 speci- Patricia de Cremoux, Anne Our results indicate that medullary mens). Atypical medullary carcinomas breast carcinoma is a distinct genetic Vincent Salomon, Stephane Liva, (eight of our 23 specimens) have a syn- subtype of breast cancer. The observa- Re ´mi 
TI - p53 Mutation as a Genetic Trait of Typical Medullary Breast Carcinoma
JF - Journal of the National Cancer Institute
DO - 10.1093/jnci/91.7.641
DA - 1999-04-07
UR - https://www.deepdyve.com/lp/oxford-university-press/p53-mutation-as-a-genetic-trait-of-typical-medullary-breast-carcinoma-mcbvbNrFpU
SP - 641
EP - 643
VL - 91
IS - 7
DP - DeepDyve
ER -