TY - JOUR
AU - 
AB - <jats:title>Abstract</jats:title>
               <jats:p>IgE/Antigen-mediated crosslinking of the high affinity IgE receptor (FcϵRI) in mast cells leads to the release of preformed, granule-stored mediators in a calcium-dependent process known as anaphylactic degranulation. Inhibition of degranulation has been proposed for the control of allergic reactions. Cannabinoid (CB) receptors have been recently found to modulate distinct immune responses. The aim of this work was to analyze the effects of the CB agonist anandamide (AEA) on the anaphylactic degranulation triggered by FcϵRI activation in murine bone marrow-derived mast cells. AEA inhibited FcϵRI-induced degranulation in a concentration-dependent manner. The inhibitory effect of AEA was not observable when degranulation was triggered by A23187+PMA or by thapsigargin (Thap). AEA inhibited maximal intracellular calcium increase in response to IgE/Ag, but intracellular calcium riseafter Thap addition was not changed. Results indicate that CB receptor activation inhibits IgE/Ag-dependent degranulation in mast cells modifying the coupling of FcϵRI with a calcium entry distinct from that dependent on intracellular store depletion</jats:p>
TI - Anandamide inhibits FcϵRI-dependent degranulation through a mechanism involving receptor-operated, but not store-operated calcium entry in mast cells (151.7)
JO - The Journal of Immunology
DO - 10.4049/jimmunol.186.supp.151.7
DA - 2011-04-01
UR - https://www.deepdyve.com/lp/crossref/anandamide-inhibits-fc-ri-dependent-degranulation-through-a-mechanism-mIHUoD0qbF
SP - 151.7
EP - 151.7
VL - 186
IS - 1_Supplement
DP - DeepDyve
ER -