TY - JOUR
AU - Silva, Joo S.
AB - CD4CD25FOXP3 regulatory T cells have long been shown to mediate susceptibility to Leishmania infection, mainly via interleukin 10 production. In this work, we showed that the main sources of interleukin 10 in peripheral blood mononuclear cells (PBMCs) from patients with cutaneous leishmaniasis due to Leishmania braziliensis are CD4CD25CD127/lowFOXP3 cells. Compared with uninfected controls, patients with CL had increased frequencies of circulating interleukin 10producing CD4CD25CD127/low cells, which efficiently suppressed tumor necrosis factor  production by the total PBMC population. Also, in CL lesions, interleukin 10 was mainly produced by CD4CD25 cells, and interleukin 10 messenger RNA expression was associated with interleukin 27, interleukin 21, and interferon  expression, rather than with FOXP3 or transforming growth factor  expressions. Active production of both interleukin 27 and interleukin 21, together with production of interferon  and interleukin 10, was also detected in the lesions. Since these cytokines are associated with the differentiation and activity of Tr-1 cells, our results suggest that this cell population may play an important role in the immunomodulation of CL. Therefore, development of treatments that interfere with this pathway may lead to faster parasite elimination.
TI - Tr-1Like CD4CD25CD127/lowFOXP3 Cells Are the Main Source of Interleukin 10 in Patients With Cutaneous Leishmaniasis Due to Leishmania braziliensis
JO - The Journal of Infectious Diseases
DO - 10.1093/infdis/jiu406
DA - 2015-03-01
UR - https://www.deepdyve.com/lp/oxford-university-press/tr-1like-cd4cd25cd127-lowfoxp3-cells-are-the-main-source-of-mCRRBZT308
SP - 708
EP - 718
VL - 211
IS - 5
DP - DeepDyve
ER -