TY - JOUR
AU1 - Thomas, H
AU2 - Müller-Enoch, D
AU3 - Lax, E R
AB - für Universität Ulm Biochemie, Abteilung 3-HYDROXY-4-METHOXYMANDELICACID, A NEW METABOLITE OF ADRENALINE AND NORADRENALINE H. D. Müller-Enoch and E.R. Thomas, Lax acid is the breakdown of adrenaline 4-hydroxy-3methoxymandelic major product is in and and found elevated in the urine of with noradrenaline, quantities patients tumours. acid can be catecholamine-producing 4-hydroxy-3-methoxymandelic in via formed the liver a of of noradrenaline or of adrenaline, weía-0-methylation two hormones. a metabolite of these acid, 3,4-dihydroxymandelic The this enzyme mediating reaction, catechol-O-methyl-transferase (EC has also been shown to the of the 2.1.1.6), methylation catalyse para-configurated of and in noradrenaline in vitro group adrenaline, hydroxyl dopamine experi¬ ments. metabolite of The doubly methylated dopamine, 3,4-dimethoxyphenylethyl- has been detected in the urine of It has been that this amine, schizophrenics. argued metabolite arises from "a disturbed catecholamine metabolism" that is to an due additional "abnormal 4-0-methylation". as to The whether the catecholamine question metabolite, 3,4-dihydroxymande¬ can at the lic be to acid, para hydroxyl group methylated produce 3-hydroxy-4- in acid has been liver Isola¬ experiments. methoxy-mandelic investigated perfusion ted rat liver was with the substrate acid, perfused 3,4-dihydroxymandelic together with L-methionine and S-adenosyl-[methyl-14C] S-adenosyl-L-methionine hydro¬ isomerie Besides the acid, gen sulphate. 4-hydroxy-3-methoxymandelic 3-hydroxy- was in the of 
TI - 3-HYDROXY-4-METHOXYMANDELIC ACID, A NEW METABOLITE OF ADRENALINE AND NORADRENALINE
JF - European Journal of Endocrinology
DO - 10.1530/acta.0.077s057
DA - 1974-04-01
UR - https://www.deepdyve.com/lp/oxford-university-press/3-hydroxy-4-methoxymandelic-acid-a-new-metabolite-of-adrenaline-and-m03P21iRRO
SP - S57
EP - S57
VL - 77
IS - 1_Supplement
DP - DeepDyve
ER -