TY - JOUR
AU - Priskorn, Lærke
AB - INTRODUCTIONReduced androgen action during foetal life affecting the development of the male reproductive system is a suspected cause of some cases of male factor infertility, which may be a result of early exposure to chemical environmental factors or other foetal exposures such as maternal exposure to stressful life events.1,2 Anogenital distance (AGD), the distance between the anus and genitals, is a well‐established marker of early androgen action in rodents and has been suggested to be so in humans as well. Thus, a link between human semen quality and AGD has been suggested,3 but this is not well‐established in human studies.In rodents, various studies have demonstrated that androgen‐driven masculinization is determined in the early period of pregnancy, called the masculinization programming window.4 One marker of rodent masculinization is AGD, which becomes longer with higher prenatal androgen exposure. Like in rodents, it is hypothesized that AGD can be a non‐invasive, lifelong marker of the androgenic action in the masculinization programming window in humans and may predict reproductive disorders such as infertility.5 Hence, AGD measurements may provide functional insights into the hidden process of foetal androgen exposure in adulthood, where fertility issues are detected. Once a better understanding is in place, AGD 
TI - Anogenital distance, male factor infertility and time to pregnancy
JF - Andrology
DO - 10.1111/andr.13161
DA - 2022-05-01
UR - https://www.deepdyve.com/lp/wiley/anogenital-distance-male-factor-infertility-and-time-to-pregnancy-luVquz0OLK
SP - 686
EP - 693
VL - 10
IS - 4
DP - DeepDyve
ER -