TY - JOUR
AU1 - Chen, Yinghua
AU2 - Li, Kang
AU3 - Zhang, Haitao
AU4 - Liu, Zhengzhao
AU5 - Chen, Duqun
AU6 - Yang, Liu
AU7 - Hu, Weixin
AB - ABSTRACTBackgroundThe aim of this study was to investigate pregnancy outcomes and risk factors in patients with lupus nephritis (LN).MethodsA total of 158 pregnancies in 155 women with LN were divided into a remission group and a control group according to whether they achieved complete renal remission (CRR) prior to pregnancy. The adverse pregnancy outcomes and risk factors were retrospectively analyzed.ResultsIn the remission group, 130 LN patients with 133 pregnancies (two twin pregnancies) delivered 127 live births; 25 LN patients with 25 pregnancies delivered 19 live births in the control group. Compared with the control group, the remission group had significantly lower incidence of LN relapse, fetal loss and premature birth. For LN patients in the remission group, a CRR duration <18 months [odds ratio (OR) 11.24, 95% confidence interval (CI) 2.95–42.80, P < 0.001] and anti-C1q antibody positivity before pregnancy (OR 7.2, 95% CI 1.38–37.41, P = 0.019) were independent risk factors for LN relapse; anti-phospholipid antibody positivity (OR 9.32, 95% CI 1.27–68.27, P = 0.028) and prednisone dosage during pregnancy ≥12.5 mg/day (OR 3.88, 95% CI 1.37–10.99, P = 0.011) were independent risk factors for fetal loss and premature birth, respectively; and age >30 years was an independent risk factor for preeclampsia and premature birth.ConclusionLN patients with a CRR duration greater than 18 months were associated with good pregnancy outcomes and lower LN relapse. Age, anti-C1q and anti-phospholipid antibodies, and prednisone dosage during pregnancy were risk factors for adverse pregnancy outcomes.
TI - Good pregnancy outcomes in lupus nephritis patients with complete renal remission
JF - Nephrology Dialysis Transplantation
DO - 10.1093/ndt/gfab289
DA - 2021-10-05
UR - https://www.deepdyve.com/lp/oxford-university-press/good-pregnancy-outcomes-in-lupus-nephritis-patients-with-complete-loFPmHE2dl
SP - 1888
EP - 1894
VL - 37
IS - 10
DP - DeepDyve
ER -