TY - JOUR
AU - Grandjean,, P
AB - Abstract Sixty patients with intermittent claudication participated in a double-blind placebo-controlled trial of 20 courses of intravenous chelation therapy with 3 g of disodium EDTA vs placebo during 5-9 weeks. After the first infusion, the 24-h urinary excretion of lead and zinc was approximately 25-fold higher in the EDTA-treated group; relative differences for copper and calcium were smaller. Urinary magnesium excretion in the EDTA-treated group was one-third less than in the control group. After the treatment period, the blood lead concentration had decreased by approximately 73% and the serum zinc concentration by approximately 34%; other changes in blood concentrations were negligible. The loss of essential minerals and the possible redistribution of lead in the body may constitute a disadvantage that should be taken into account in repeated intravenous EDTA treatment. This content is only available as a PDF. © 1996 The American Association of Clinical Chemists, Inc. This article is published and distributed under the terms of the Oxford University Press, Standard Journals Publication Model (https://academic.oup.com/journals/pages/open_access/funder_policies/chorus/standard_publication_model)
TI - Metal excretion and magnesium retention in patients with intermittent claudication treated with intravenous disodium EDTA
JF - Clinical Chemistry
DO - 10.1093/clinchem/42.12.1938
DA - 1996-12-01
UR - https://www.deepdyve.com/lp/oxford-university-press/metal-excretion-and-magnesium-retention-in-patients-with-intermittent-ll4CAkLU8C
SP - 1938
EP - 1942
VL - 42
IS - 12
DP - DeepDyve
ER -