TY - JOUR
AU1 - Betrains, Albrecht
AU2 - Moreel, Lien
AU3 - Wright, William Floyd
AU4 - Blockmans, Daniel
AU5 - Vanderschueren, Steven
AB - Internal and Emergency Medicine https://doi.org/10.1007/s11739-023-03293-w CE-RESEARCH LE T TER TO  THE   EDITOR Negative 18F‑FDG‑PET imaging in fever and inflammation of unknown origin: now what? 1,2 1,2 3 1,2,4 1,2,4 Albrecht Betrains  · Lien Moreel  · William Floyd Wright  · Daniel Blockmans  · Steven Vanderschueren Received: 21 February 2023 / Accepted: 22 April 2023 © The Author(s), under exclusive licence to Società Italiana di Medicina Interna (SIMI) 2023 Keywords FUO · IUO · 18F-FDG-PET Dear Editor, Methods 18F-fluorodeoxyglucose positron emission tomography We retrospectively identified patients (≥ 18 years) meet- (FDG-PET) is an important second-line test in fever of ing the criteria for FUO or IUO between January 2000 and unknown origin (FUO) and inflammation of unknown ori- December 2019 from a registry of the general internal medi- gin (IUO) when there are few or no potential diagnostic cine department of the University Hospitals Leuven (Bel- clues. A meta-analysis showed that FDG-PET had a sensi- gium). FUO was defined as an illness duration of ≥ 3 weeks tivity of 84% (95% CI 79–89%) and specificity of 63% (95% with fever ≥ 38.3  °C on ≥ 3 occasions and no diagnosis CI 49–75%) in a case mix of FUO/IUO [1]. Occasionally, despite baseline investigations (Table S1). IUO was defined FDG-PET cannot identify any abnormalities. In 
TI - Negative 18F-FDG-PET imaging in fever and inflammation of unknown origin: now what?
JF - Internal and Emergency Medicine
DO - 10.1007/s11739-023-03293-w
DA - 2023-09-01
UR - https://www.deepdyve.com/lp/springer-journals/negative-18f-fdg-pet-imaging-in-fever-and-inflammation-of-unknown-lcusI1WV0p
SP - 1865
EP - 1869
VL - 18
IS - 6
DP - DeepDyve
ER -