TY - JOUR
AU - Menezes, Gustavo
AB - Inflamm. Res. (2018) 67:77–88 https://doi.org/10.1007/s00011-017-1098-3 Inflammation Research ORIGINAL RESEARCH PAPER IL-33 signalling in liver immune cells enhances drug-induced liver injury and inflammation 1 1 1 1 Maísa Mota Antunes  · Alan Moreira Araújo  · Ariane Barros Diniz  · Rafaela Vaz Sousa Pereira  · 1 1 2 1 Débora Moreira Alvarenga  · Bruna Araújo David  · Renata Monti Rocha  · Maria Alice Freitas Lopes  · 1 1 1 2 3 Sarah Cozzer Marchesi  · Brenda Naemi Nakagaki  · Érika Carvalho  · Pedro Elias Marques  · Bernhard Ryffel  · 3 4 5 1 Valérie Quesniaux  · Rodrigo Guabiraba Brito  · José Carlos Alves Filho  · Denise Carmona Cara  · 6 1 Rafael Machado Rezende  · Gustavo Batista Menezes   Received: 14 July 2017 / Revised: 15 September 2017 / Accepted: 27 September 2017 / Published online: 14 October 2017 © Springer International Publishing AG 2017 Abstract Results Acetaminophen overdose caused a massive necro- Objective and design The aim of this study was to inves- sis and accumulation of immune cells within the liver, con- tigate the contribution of IL-33/ST2 axis in the onset and comitantly with IL-33 and chemokine release. Liver non- progression of acute liver injury using a mice model of drug- parenchymal cells were the major sensors for IL-33, and induced liver injury (DILI). amongst them, neutrophils were the major players in ampli- Material and treatments DILI was induced by overdose fication of the inflammatory response triggered by IL-33/ 
TI - IL-33 signalling in liver immune cells enhances drug-induced liver injury and inflammation
JF - Inflammation Research
DO - 10.1007/s00011-017-1098-3
DA - 2017-10-14
UR - https://www.deepdyve.com/lp/springer-journals/il-33-signalling-in-liver-immune-cells-enhances-drug-induced-liver-lMILozwcq0
SP - 77
EP - 88
VL - 67
IS - 1
DP - DeepDyve
ER -