TY - JOUR
AU - Wang, K. K. W.
AB - q Birkhauser Verlag, Basel, 1997 Inflamm. res. 46, Supplement 2 (1997) S151– S152 1023-3830/97/02S151-02 $ 1.50+0.20/0 Inflammation Research V. Cytokines and apoptosis Apoptotic death induced in MOLT-4 T-lymphoblasts by purine nucleoside phosphorylase inhibition 1 1;2 2 2 R. B. Gilbertsen , R. Posmantur , R. Nath and K. K. W. Wang Department of Immunopathology, Parke-Davis Pharmaceutical Research, 2800 Plymouth Road, Ann Arbor, MI 48105, USA, Fax +1 313 996 4333, e-mail: GILBERR@AA.WL.COM Department of Neuroscience Therapeutics, Parke-Davis Pharmaceutical Research, 2800 Plymouth Road, Ann Arbor, MI 48105, USA Introduction Results and discussion Congenital homozygous deficiency of purine nucleoside Co-culturing of MOLT-4 cells with CI-1000 and dGuo had phosphorylase (PNP, EC 2.4.2.1) results in an immune minimal effect on cell viability after 24 h of culture, but deficiency syndrome affecting T lymphocytes [1]. PNP viability was decreased in a dGuo concentration-dependent inhibitors are growth inhibitory to human T lymphoblastoid manner after 48 h (Fig. 1A). Cultures treated with 10 or cell lines when cultured with the PNP substrate 2 - 30 mM dGuo in the absence of CI-1000 were >90% viable, deoxyguanosine (dGuo) [2 – 5]. In this paradigm, it has whereas viability was reduced to 66% and 46% of control, 
TI - Apoptotic death induced in MOLT-4 T-lymphoblasts by purine nucleoside phosphorylase inhibition
JF - Inflammation Research
DO - 10.1007/s000110050150
DA - 1997-08-01
UR - https://www.deepdyve.com/lp/springer-journals/apoptotic-death-induced-in-molt-4-t-lymphoblasts-by-purine-nucleoside-lBEg6saM3e
SP - 151
EP - 152
VL - 46
IS - 2
DP - DeepDyve
ER -