TY - JOUR
AU - Bugni, Tim S.
AB - Forazoline A, a novel antifungal polyketide with in vivo efficacy against Candida albicans, was discovered using LCMS‐based metabolomics to investigate marine‐invertebrate‐associated bacteria. Forazoline A had a highly unusual and unprecedented skeleton. Acquisition of 13C–13C gCOSY and 13C–15N HMQC NMR data provided the direct carbon–carbon and carbon–nitrogen connectivity, respectively. This approach represents the first example of determining direct 13C–15N connectivity for a natural product. Using yeast chemical genomics, we propose that forazoline A operated through a new mechanism of action with a phenotypic outcome of disrupting membrane integrity.
TI - Forazoline A: Marine‐Derived Polyketide with Antifungal In Vivo Efficacy
JF - Angewandte Chemie International Edition
DO - 10.1002/anie.201405990
DA - 2015-08-20
UR - https://www.deepdyve.com/lp/wiley/forazoline-a-marine-derived-polyketide-with-antifungal-in-vivo-l1br0KE4Wl
SP - 11583
EP - 11586
VL - 53
IS - 43
DP - DeepDyve
ER -