TY - JOUR
AU - Wang, Zhenlong
AB - INTRODUCTIONWhen animals experience stimuli that arouse their fear or disgust, they demonstrate a strong physiological and psychological stress response accompanied by defensive behaviors.1 In particular, rodents typically exhibit appropriate innate defensive behaviors based on the threat's urgency and the environment's complexity,2 such as flight, freezing, and defensive aggression.3,4 Flight and freezing are the two most vital innate defensive behaviors that mice exhibit to avoid natural enemies,5 but how the brain processes and transmits quickly threat information and then generates appropriate defensive responses needs to be further studied.Researchers have designed many experimental paradigms in the laboratory based on sight, smell, or hearing to induce fear responses in rodents by simulating threats in the natural environment.6–9 In visual stimuli, rapidly expanding black discs (looming) proved to simulate an approaching predator in the sky, which can induce flight behavior in mice.10 Another study found that mice tended to choose a flight behavior when they dealt with an approaching predator in the sky, whereas they were more likely to freeze when they faced a hovering predator.11 Studies have shown that the subcortical visual pathway plays a vital role during the processing of fear visual information,12–14 and the periaqueductal gray (PAG) is the last 
TI - Different coding characteristics between flight and freezing in dorsal periaqueductal gray of mice during exposure to innate threats
JO - Animal Models and Experimental Medicine
DO - 10.1002/ame2.12276
DA - 2022-12-01
UR - https://www.deepdyve.com/lp/wiley/different-coding-characteristics-between-flight-and-freezing-in-dorsal-l0cBpLUTWM
SP - 491
EP - 501
VL - 5
IS - 6
DP - DeepDyve
ER -