TY - JOUR
AU - Gleicher, Norbert
AB - Purpose To investigate the effects of dehydroepiandrosterone (DHEA) supplementation on female sexual function in premenopausal infertile women of advanced ages. Methods This observational study was conducted in an academically affiliated private fertility center. Patients included 87 premenopausal infertile women, 50 of whom completed the study including the Female Sexual Function Index (FSFI) questionnaires and comprehensive endocrine evaluation before and 4–8 weeks after initiating 25 mg of oral micronized DHEA TID. Results Age of patients was 41.1 ± 4.2 years, BMI 24.4 ± 6.1 kg/m , 86% were married, and 42% were parous. Following supplementation with DHEA, all serum androgen levels increased (each P < 0.0001), while FSH levels decreased by 2.6 ± 4.4 from a baseline of 10.3 ± 5.4 mIU/mL (P = 0.009). The FSFI score for the whole study group increased by 7% (from 27.2 ± 6.9 to 29.2 ± 5.6; P = 0.0166). Domain scores for desire increased by 17% (P = 0.0004) and by 12% for arousal (P = 0.0122); lubrication demonstrated an 8% trend towards improvement (P = 0.0551), while no changes in domain scores for orgasm, satisfaction, or pain were observed. Women in the lowest starting FSFI score quartile (<25.7), experienced a 6.1 
TI - Effects of dehydroepiandrosterone (DHEA) supplementation on sexual function in premenopausal infertile women
JF - Endocrine
DO - 10.1007/s12020-018-1781-3
DA - 2018-10-11
UR - https://www.deepdyve.com/lp/springer-journals/effects-of-dehydroepiandrosterone-dhea-supplementation-on-sexual-kpPB3FzIvW
SP - 632
EP - 638
VL - 63
IS - 3
DP - DeepDyve
ER -