TY - JOUR
AU - Yin, Zhinan
AB - Background. T cells comprise a small subset of T cells and play a protective role against cancer and viral infections; however, their precise role in patients with chronic hepatitis B remains unclear.Methods.Flow cytometry and immunofunctional assays were performed to analyze the impact of V2  (V2) T cells in 64 immune-activated patients, 22 immune-tolerant carriers, and 30 healthy controls.Results.The frequencies of peripheral and hepatic V2 T cells decreased with disease progression from immune tolerant to immune activated. In the latter group of patients, the decreases in peripheral and intrahepatic frequencies of V2 T cells reversely correlated with alanine aminotransferase levels and histological activity index. These activated terminally differentiated memory phenotypic V2 T cells exhibited impaired abilities in proliferation and chemotaxis, while maintained a relative intact interferon (IFN)  production. Importantly, V2 T cells, in vitro, significantly suppressed the production of cytokines associated with interleukin 17producing CD4 T (Th17) cells through both cell contactdependent and IFN-dependent mechanisms.Conclusions.Inflammatory microenvironment in IA patients result in decreased numbers of V2 T cells, which play a novel role by regulating the pathogenic Th17 response to protect the liver in patients with chronic hepatitis B.
TI - Decreased V2  T Cells Associated With Liver Damage by Regulation of Th17 Response in Patients With Chronic Hepatitis B
JO - The Journal of Infectious Diseases
DO - 10.1093/infdis/jit312
DA - 2013-10-15
UR - https://www.deepdyve.com/lp/oxford-university-press/decreased-v2-t-cells-associated-with-liver-damage-by-regulation-of-kneH0L8Ht5
SP - 1294
EP - 1304
VL - 208
IS - 8
DP - DeepDyve
ER -