TY - JOUR
AU - Remington, Jack, S.
AB - Abstract A retrospective, clinical, epidemiologic, and risk-factor analysis was performed on 21 recipients of cardiac allografts who had experienced nocardiosis since the inception of the cardiac transplantation program at Stanford University Medical Center in 1968. The lung was the primary and only detectable site of infection in 17 (81%) of 21 patients, and there were three cases of disseminated disease. Presenting symptoms were either nonspecific (dry cough and fever) or absent (in 40%). The time of onset of infection following transplantation was variable (range, 43–982 days), and there was no period of peak incidence. Epidemiologic and risk-factor analysis failed to identify a nosocomial point-source or specific parameters that predisposed a patient to nocardial infection. Nocardiosis was not associated with the onset of primary infection with cytomegalovirus following transplantation. However, an association between pulmonary nocardiosis and subsequent development of nontuberculous mycobacteriosis was established in five of the 21 patients. All patients with nocardiosis were treated primarily with sulfisoxazole (6–12 g per day) for a mean of 13.2 months. No deaths were attributable to nocardial infection, nor could acquisition of the infection be shown to affect overall survival. The results of the study support an aggressive approach to diagnosis of infections in the immunocompromised host and suggest that a favorable therapeutic outcome may be anticipated in such individuals who sustain nocardiosis if the diagnosis is made early in the course of the infection and if appropriate antimicrobial therapy is instituted. This content is only available as a PDF. Author notes * Present address: Divisions of Infectious Disease and Tropical and Geographic Medicine, University of New Mexico School of Medicine, Albuquerque, New Mexico 87131. † Present address: Division of Biostatistics, Department of Family and Community Medicine, University of Utah College of Medicine, Salt Lake City, Utah 84132. © 1981 by The University of Chicago
TI - Nocardial Infections in the Immunocompromised Host: A Detailed Study in a Defined Population
JF - Clinical Infectious Diseases
DO - 10.1093/clinids/3.3.492
DA - 1981-05-01
UR - https://www.deepdyve.com/lp/oxford-university-press/nocardial-infections-in-the-immunocompromised-host-a-detailed-study-in-knOnJpJnYS
SP - 492
EP - 507
VL - 3
IS - 3
DP - DeepDyve
ER -