TY - JOUR
AU1 - Hoskins, Lansing C.
AB - THE JOURNAL OF INFECTIOUS DISEASES. VOL. 137, NO.5. ~JAY 1978 © 1978 by the University of Chicago. 0022-1899/78/3705-0010$00.75 From the Gastroenterology Section, Lansing C. Hoskins Veterans Administration Hospital, and theDepartment oj Medicine, Case Western Reserve University School of Medicine, Cleveland, Ohio In considering potential hazards of recombinant testine, and 2-5 X 10 cells/min in the colon. DNA research, it is useful to note that the mam­ These data for the small intestine agree reason­ malian gut lumen harbors two major pools of ably well with shedding rates of 80-90 X 10 cells/ DNA: eucaryotic DNA in cells shed from the min computed by Crosby [3] from epithelial turn­ mucosal epithelium and procaryotic DNA in the over rates, with substitution of the measured indigenous microflora. Gut epithelium has a high human villus epithelial migration rate of five rate of renewal which under normal circumstances to six days [4] instead of three days which Crosby matches an equally high rate of shedding. The assumed. Humans and rats have nearly the same indigenous microflora comprises both ingested DNA content per cell [5, 6]; in the small intestinal bacteria (a minor component) and comparatively epithelium of the rat, this value is about 7 
TI - Host and Microbial DNA in the Gut Lumen
JF - The Journal of Infectious Diseases
DO - 10.1093/infdis/137.5.694
DA - 1978-05-01
UR - https://www.deepdyve.com/lp/oxford-university-press/host-and-microbial-dna-in-the-gut-lumen-kfuffW06tW
SP - 694
EP - 698
VL - 137
IS - 5
DP - DeepDyve
ER -