TY - JOUR
AU - RUSSELL, A., S.
AB - Abstract We followed all 128 patients started on methotrexate (MTX) for rheumatoid arthritis (RA) over a 4-year period. Forty-nine were followed for over 3 years. Forty-three patients discontinued treatment, 23 because of toxicity, 15 for inefficacy and five for other reasons. Forty-seven of the 75 followed on treatment for over 2 years had hand radiographs available before and after this treatment period. None showed improvement and 15 showed marked deterioration. Patients' acceptance of this therapy was good although most were noted objectively to have persistent disease activity. We would recommend that if MTX is to be used, a more aggressive approach be adopted to reduce not only the symptoms but the signs of active disease. Disease-modifying antirheumatic drugs, Side effects, Radiographs, Haematology, Liver, Kidney This content is only available as a PDF. © 1989 Oxford University Press
TI - PROSPECTIVE LONG TERM FOLLOW-UP OF METHOTREXATE THERAPY IN RHEUMATOID ARTHRITIS: TOXICITY, EFFICACY AND RADIOLOGICAL PROGRESSION
JF - Rheumatology
DO - 10.1093/rheumatology/28.2.147
DA - 1989-04-01
UR - https://www.deepdyve.com/lp/oxford-university-press/prospective-long-term-follow-up-of-methotrexate-therapy-in-rheumatoid-kHz5RbstQQ
SP - 147
EP - 153
VL - 28
IS - 2
DP - DeepDyve
ER -