TY - JOUR
AU - HANES, CHARLES S.
AB - FORMATION OF PEPT1DES IN ENZYMIC REACTIONS Charles S. Hones The primary condensation reactions, probably relatively few in number, lead to the synthesis de novo of condensed molecules; it is the anhydro-linkages of these products of primary condensation which, as a result of being substituted and re-substituted, supply the condensing capacity of the cell. While knowledge of this class of reaction as a whole remains THE FORMATION OF PEPT1DES imperfect, the known examples are the so-called coupled IN ENZYMIC REACTIONS oxidation and phosphorylation reactions. In these, carboxyl phosphates (or related condensed molecules) are formed, the result apparently of dehydrogenation of a carbonyl addition CHARLES S. HANES Ph.D. ScD. F.R.S. compound. The formation of a carboxyl phosphate or similar Department of Biochemistry, University of Toronto, Canada bond is accompanied by a large increase in the free energy, as was shown by Lipmann (1941), so that an essential con- dition for its formation in significant amounts is that there be a 1 Biological processes of condensation 2 Synthesis of peptide bonds in ATP-dependent concomitant transformation characterized by a compensating condensations decrease in the free energy, e.g., the oxidation. 3 Transpeptidation and transamidation reactions The other class of reactions known to form stages 
TI - THE FORMATION OF PEPTIDES IN ENZYMIC REACTIONS
JO - British Medical Bulletin
DO - 10.1093/oxfordjournals.bmb.a074328
DA - 1953-01-01
UR - https://www.deepdyve.com/lp/oxford-university-press/the-formation-of-peptides-in-enzymic-reactions-k5pGWxUV0r
SP - 131
EP - 134
VL - 9
IS - 2
DP - DeepDyve
ER -