TY - JOUR
AU - Savory,, J
AB - Abstract We evaluated the performance of the lithium ion-selective electrode (ISE) in the Du Pont Na/K/Li analyzer. Lithium concentrations in 106 serum samples from patients being treated with lithium were measured in duplicate with the ISE and by flame photometry. The slope of the regression line for the two methods was 1.004 with a standard error of the estimate of 0.049 mmol/L (x = flame photometry, y = ISE). Lithium measurements by the ISE method in serum or aqueous standards were linear to greater than 2.0 mmol/L. Within-run CVs for low (0.31 mmol/L) and high (1.15 mmol/L) lithium controls were 5.9% and 1.7%, respectively (n = 20). Day-to-day CVs for the same controls were 9.8% and 3.3%, respectively (n = 20). There was no significant interference when the concentrations of sodium, potassium, calcium, or magnesium were varied, nor did intervening urinary lithium analyses affect the measurement of serum lithium. Results for lithium measurement in four serum-based survey materials compared well with results by isotope dilution/mass spectrometry. This content is only available as a PDF. © 1988 The American Association for Clinical Chemistry, Inc. This article is published and distributed under the terms of the Oxford University Press, Standard Journals Publication Model (https://academic.oup.com/journals/pages/open_access/funder_policies/chorus/standard_publication_model)
TI - Lithium determined in serum with an ion-selective electrode.
JF - Clinical Chemistry
DO - 10.1093/clinchem/34.7.1500
DA - 1988-07-01
UR - https://www.deepdyve.com/lp/oxford-university-press/lithium-determined-in-serum-with-an-ion-selective-electrode-k3QMHUVjSK
SP - 1500
EP - 1502
VL - 34
IS - 7
DP - DeepDyve
ER -