TY - JOUR
AU1 - Innaro, Nadia
AU2 - Gervasi, Rita
AU3 - Ferrazzo, Teresa
AU4 - Garo, Nastassia C.
AU5 - Curto, Lucia S.
AU6 - Lavecchia, Annamaria
AU7 - Aquila, Isabella
AU8 - Donato, Giuseppe
AU9 - Malara, Natalia
AB - The overall estimated risk of recurrence after an apparently complete thyroid cancer resection ranges from <1% to 55%, and the high‐quality pathology report is crucial for proper risk stratification. The neck ultrasound (US) and serum thyroglobulin (Tg) and anti‐Tg antibody (TgAb) assays are the mainstays for Differentiated Thyroid Cancer (DTC) follow‐up. However, the neck US includes a high frequency of nonspecific findings and despite the serum, Tg unmasks the presence of thyrocytes, it is not discriminating between normal and malignant cells. In this study, to improve post‐surgery follow‐up of minimal residual disease in papillary thyroid cancer (PTC) patients, blood‐derived cytology specimens were evaluated for the presence of circulating tumor cells (CTCs). The presence of CTCs of thyroid origin was confirmed by cytomorphological and tissue‐specific antigens analysis (Thyroid Transcription Factor‐1/TTF‐1 and Tg) and proliferative profile (percentage of cells in S‐phase). Our data revealed an unfavorable’ prognostic risk in patients with >5% CTCs (p = 0.09) and with >30% S‐phase cells at baseline (p = 0.0015), predicting ≤1 year relapsing lesion event. These results suggest a new intriguing frontier of precision oncology forefront cytology‐based liquid biopsy.
TI - Minimal residual disease assessment of papillary thyroid carcinoma through circulating tumor cell‐based cytology
JF - Cancer Medicine
DO - 10.1002/cam4.4813
DA - 2022-12-01
UR - https://www.deepdyve.com/lp/wiley/minimal-residual-disease-assessment-of-papillary-thyroid-carcinoma-k2ScgxpDa0
SP - 4830
EP - 4837
VL - 11
IS - 24
DP - DeepDyve
ER -