TY - JOUR
AU - S, Sperling,
AB - Objective: To identify the structure of cognitive domains underlying neuropsychological assessments in patients with advanced Parkinson’s disease (PD), in order to facilitate improved validity of cognitive research in this population. Method: We analyzed a primarily pre-surgical clinical cohort of 432 patients with PD. Patients were administered neuropsychological evaluations that included: Stroop Color and Word Test (SCWT), Wechsler Adult Intelligence Scale-IV Digit Span (DS) and Matrix Reasoning (MR), letter (FAS) and category (Animals) fluency, Trail Making Test (TMT), Wisconsin Cart Sorting Test-64 (WCST-64), Hopkins Verbal Learning Test-Revised (HVLT-R), and the Brief Visuospatial Memory Test-Revised (BVMT-R). We employed exploratory factor analysis (EFA), using principal axis factoring and oblique direct oblimin rotation, to identify underlying cognitive domains. The optimal model was determined based on eigenvalues, cumulative variance, and scree plot inspection. Results: The EFA yielded a four-factor solution that explained 73.57% of the total variance (Table 1). SCWT Color Naming and Word Reading, FAS and Animals, TMT Parts A and B, DS, and MR loaded on the first factor, representing Processing Speed and Attention/Working Memory. WCST-64 Perseverative Responses and Total Errors loaded onto the second factor, representing Concept Formation/Perseveration. BVMT-R Total Learning and Delayed Recall and Stroop Interference comprised the third factor, representing Visual Attention and Memory. HVLT-R Total Learning and Delayed Recall loaded on the fourth factor, representing Verbal Learning and Memory. Conclusions: These four dimensions may best represent the neurocognitive domains in advanced PD. Future studies should take caution using theory alone when classifying neuropsychological tests as markers of a specific cognitive domain. View largeDownload slide View largeDownload slide © The Author(s) 2018. Published by Oxford University Press. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com. This article is published and distributed under the terms of the Oxford University Press, Standard Journals Publication Model (https://academic.oup.com/journals/pages/open_access/funder_policies/chorus/standard_publication_model)
TI - Aging & Dementia - 2The Neurocognitive Domains of Advanced Parkinson’s Disease
JF - Archives of Clinical Neuropsychology
DO - 10.1093/arclin/acy060.02
DA - 2018-09-01
UR - https://www.deepdyve.com/lp/oxford-university-press/aging-dementia-2the-neurocognitive-domains-of-advanced-parkinson-s-k0dqa3mb0S
SP - 692
VL - 33
IS - 6
DP - DeepDyve
ER -